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The regulated secretory pathway in CD4+ T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse

Abstract:

Direct cell-cell spread of Human Immunodeficiency Virus type-1 (HIV-1) at the virological synapse (VS) is an efficient mode of dissemination between CD4⁺T cells but the mechanisms by which HIV-1 proteins are directed towards intercellular contacts is unclear. We have used confocal microscopy and electron tomography coupled with functional virology and cell biology of primary CD4⁺T cells from normal individuals and patients with Chediak-Higashi Syndrome and report that the HIV-1 VS displays a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Institution:
University College London, UK
Department:
MRC Centre for Medical Molecular Virology,Division of Infection and Immunity
Role:
Author
More by this author
Institution:
"University of Oxford", "European Molecular Biology Laboratory, Heidelberg, Germany"
Department:
Structural and Computational Biology Unit
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Name:
Medical Research Council
Funding agency for:
Jolly, C
Grant:
G0800312
More from this funder
Name:
"Medical Research Council", "Bill and Melinda Gates Foundation", "International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Consortium", "Fondation Dormeur"
Funding agency for:
Sattentau, Q
Publisher:
Public Library of Science
Journal:
PLoS Pathogens More from this journal
Volume:
7
Issue:
9
Article number:
e1002226
Publication date:
2011-09-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Language:
English
Subjects:
UUID:
uuid:067b6a22-05fe-4e01-8bff-d3870e5dedf4
Local pid:
ora:5897
Deposit date:
2011-11-11

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