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Journal article

Gene therapy targeting inflammation in atherosclerosis.

Abstract:

The extensive cross-talk between the immune system and vasculature leading to the infiltration of immune cells into the vascular wall is a major step in atherogenesis. In this process, reactive oxygen species play a crucial role, by inducing the oxidation of LDL and the formation of foam cells, and by activating a number of redox-sensitive transcriptional factors such as nuclear factor kappa B (NFkappa B) or activating protein 1 (AP1), that regulate the expression of multiple pro/anti inflamm...

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Publication status:
Published

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Publisher copy:
10.2174/138161211798764799

Authors


Van-Assche, T More by this author
Huygelen, V More by this author
Crabtree, MJ More by this author
Antoniades, C More by this author
Journal:
Current pharmaceutical design
Volume:
17
Issue:
37
Pages:
4210-4223
Publication date:
2011-12-05
DOI:
EISSN:
1873-4286
ISSN:
1381-6128
URN:
uuid:067a899b-5565-453e-b836-e4211b23a451
Source identifiers:
223324
Local pid:
pubs:223324

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