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RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

Abstract:

The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL fusion proteins have distinct leukemic phenotypes even when expressed in the same cell type, but how this distinction is delineated on a molecular level is poorly understood. Here, we highlight a unique molecular mechanism whereby t...

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Authors


Wilkinson, AC More by this author
Ballabio, E More by this author
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Journal:
Cell Reports
Volume:
3
Issue:
1
Pages:
116-127
Publication date:
2013-01-31
DOI:
EISSN:
2211-1247
URN:
uuid:0678e83a-7ea1-4479-bc5e-96b937c167d3
Source identifiers:
385044
Local pid:
pubs:385044

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