Journal article
RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction
- Abstract:
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The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL fusion proteins have distinct leukemic phenotypes even when expressed in the same cell type, but how this distinction is delineated on a molecular level is poorly understood. Here, we highlight a unique molecular mechanism whereby t...
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- Publisher copy:
- 10.1016/j.celrep.2012.12.016
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Bibliographic Details
- Journal:
- Cell Reports
- Volume:
- 3
- Issue:
- 1
- Pages:
- 116-127
- Publication date:
- 2013-01-31
- DOI:
- EISSN:
-
2211-1247
- URN:
-
uuid:0678e83a-7ea1-4479-bc5e-96b937c167d3
- Source identifiers:
-
385044
- Local pid:
- pubs:385044
Terms of use
- Copyright date:
- 2013
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