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Journal article

LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis.

Abstract:

OBJECTIVE: Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells. Since activated T cells have been implicated in osteoclastogenesis in rheumatoid arthritis (RA), this study sought to determine whether LIGHT can regulate RANKL/cytokine-induced osteoclast formation, to identify the mechanis...

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Publication status:
Published

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Publisher copy:
10.1002/art.21821

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Arthritis and rheumatism
Volume:
54
Issue:
5
Pages:
1451-1462
Publication date:
2006-05-01
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
Source identifiers:
103867

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