Journal article
A randomised controlled trial of a low-carbohydrate digitally-supported weight loss programme for type 2 diabetes
- Abstract:
- We evaluated the effectiveness of a low-carbohydrate digitally-supported weight loss programme for glycaemic control for people with type 2 diabetes (T2D) compared with usual primary care in a 12 month RCT. We individually randomised 115 people with T2D and BMI ≥27kg/m2 recruited from 19 general practices in England, to receive either a 12-week low-carbohydrate programme with digital support, or usual care. There was no between-group difference in HbA1c change from baseline to 3 or 12 months (primary outcome; estimated mean difference (95% CI) -0.7mmol/mol (-5.0 to 3.6), and -1.5 (-5.7 to 2.8), p=0.80). Greater mean weight loss in the intervention group at 3 months (2.6kg (0.6 to 4.6)), was not sustained by 12 months (-0.4kg (-2.3 to 1.6)). While this digitallydelivered intervention was acceptable to patients, there was no evidence of a meaningful impact of the intervention on glycaemia or other cardiovascular risk factors beyond that achieved with usual care. This trial was prospectively registered at clinicaltrials.gov, NCT04916314, in June 2021.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 732.0KB, Terms of use)
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- Publisher copy:
- 10.1038/s41746-025-02116-w
Authors
- Publisher:
- Springer Nature
- Journal:
- npj Digital Medicine More from this journal
- Volume:
- 8
- Issue:
- 1
- Article number:
- 739
- Publication date:
- 2025-12-02
- Acceptance date:
- 2025-10-26
- DOI:
- EISSN:
-
2398-6352
- ISSN:
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2398-6352
- Language:
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English
- Pubs id:
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2325835
- Local pid:
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pubs:2325835
- Deposit date:
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2025-11-13
- ARK identifier:
Terms of use
- Copyright holder:
- Morris et al
- Copyright date:
- 2025
- Rights statement:
- © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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