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Repeat protein architectures predicted by a continuum representation of fold space.

Abstract:

It is an open question whether nature has utilized all possible protein folds. For a simple protein architecture, the helical repeats, we report a method to address this question based on a mapping between the set of repetitive curves and a space of parameters specifying the curve. The exploration of the parameter space for a particular architecture enables a systematic exploration of the fold space for that protein architecture. In a planar subspace of the parameter space of helical repeats ...

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Publication status:
Published

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Publisher copy:
10.1110/ps.051971106

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Journal:
Protein science : a publication of the Protein Society
Volume:
15
Issue:
4
Pages:
753-760
Publication date:
2006-04-01
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
Source identifiers:
188415
Language:
English
Keywords:
Pubs id:
pubs:188415
UUID:
uuid:066a6eac-0016-4802-820e-603e714ae282
Local pid:
pubs:188415
Deposit date:
2013-11-16

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