Repeat protein architectures predicted by a continuum representation of fold space.

Journal article

It is an open question whether nature has utilized all possible protein folds. For a simple protein architecture, the helical repeats, we report a method to address this question based on a mapping between the set of repetitive curves and a space of parameters specifying the curve. The exploration of the parameter space for a particular architecture enables a systematic exploration of the fold space for that protein architecture. In a planar subspace of the parameter space of helical repeats ...

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Authors: Hausrath, A; Goriely, A

• Publication status: Published
• Journal: Protein science : a publication of the Protein Society
• Volume: 15
• Issue: 4
• Pages: 753-760
• Publication date: 2006-04-01
• DOI: 10.1110/ps.051971106
• EISSN: 1469-896X
• ISSN: 0961-8368
• Language: English
• Keywords: Protein Conformation; Algorithms; Protein Folding; Models, Molecular; Computer Graphics; Databases, Protein