- Abstract:
-
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/nature09410
-
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- Journal:
- Nature
- Volume:
- 467
- Issue:
- 7317
- Pages:
- 832-838
- Publication date:
- 2010-10-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:066a5c82-d1c4-4bff-b0e0-76d2ddd55673
- Source identifiers:
-
90943
- Local pid:
- pubs:90943
- Copyright date:
- 2010
Journal article
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
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