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Journal article

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Abstract:

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, ...

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Publication status:
Published

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Publisher copy:
10.1038/nature09410

Authors


Lango Allen, H More by this author
Estrada, K More by this author
Berndt, SI More by this author
Weedon, MN More by this author
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Journal:
Nature
Volume:
467
Issue:
7317
Pages:
832-838
Publication date:
2010-10-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:066a5c82-d1c4-4bff-b0e0-76d2ddd55673
Source identifiers:
90943
Local pid:
pubs:90943

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