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Germline CDH1 mutations in bilateral lobular carcinoma in situ.

Abstract:

BACKGROUND: Invasive lobular breast cancer (ILC) and lobular carcinoma in situ (LCIS) are characterised by loss of E-cadherin expression. However germline CDH1 mutations are rare in cases of ILC with no family history of hereditary diffuse gastric cancer (HDGC) and have not been described in women with LCIS. METHODS: We screened the CDH1 gene in 50 cases of bilateral LCIS/ILC using Sanger sequencing and MLPA. RESULTS: Sanger sequencing revealed four pathogenic germline mutations, including a ...

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Publication status:
Published

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Publisher copy:
10.1038/bjc.2013.792

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Journal:
British journal of cancer More from this journal
Volume:
110
Issue:
4
Pages:
1053-1057
Publication date:
2014-02-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Language:
English
Keywords:
Pubs id:
pubs:444254
UUID:
uuid:0669aaca-6c83-4255-9c2a-75c66a16b600
Local pid:
pubs:444254
Source identifiers:
444254
Deposit date:
2014-02-08

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