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Smad-dependent alterations of PPT cholinergic neurons as a pathophysiological mechanism of age-related sleep-dependent memory impairments.

Abstract:

In humans, memory impairments are highly prevalent in the aged population, but their functional and structural origins are still unknown. We hypothesized that circadian rhythm alterations may predict spatial memory impairment in aged rats. We demonstrate an association between sleep/wake circadian rhythm disturbances (non-REM sleep fragmentation) and spatial memory impairments in aged rats. We show by light and electron microscopy that these age-related disruptions in circadian rhythm and spa...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Neurobiology of aging More from this journal
Volume:
27
Issue:
12
Pages:
1848-1858
Publication date:
2006-12-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Language:
English
Keywords:
Pubs id:
pubs:329234
UUID:
uuid:0665e4b5-c1a0-4f16-896d-8db99896e4c8
Local pid:
pubs:329234
Source identifiers:
329234
Deposit date:
2013-11-16

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