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Journal article

Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.

Abstract:

In Mycobacterium tuberculosis, the genes hsaD (2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase) and nat (arylamine N-acetyltransferase) are essential for survival inside of host macrophages. These genes act as an operon and have been suggested to be involved in cholesterol metabolism. However, the role of NAT in this catabolic pathway has not been determined. In an effort to better understand the function of these proteins, we have expressed, purified and characterized TBNAT (NAT from...

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Publication status:
Published

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Publisher copy:
10.1042/bj20082011

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry, BHF Centre of Research Excellence
Role:
Author
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Journal:
The Biochemical journal
Volume:
418
Issue:
2
Pages:
369-378
Publication date:
2009-03-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:066333db-4fa4-4f6e-a2e3-8b6ac5f1fc12
Source identifiers:
58754
Local pid:
pubs:58754

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