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CD8+ T cell responses to human immunodeficiency viruses type 2 (HIV-2) and type 1 (HIV-1) gag proteins are distinguishable by magnitude and breadth but not cellular phenotype.

Abstract:

The mechanisms underlying the relatively slow progression of human immunodeficiency virus type 2 (HIV-2) compared with HIV-1 infection are undefined and could be a result of more effective immune responses. We used HIV-2 and HIV-1 IFN-gamma enzyme-linked immunospot assays to evaluate CD8(+) T cell responses in antiretroviral-naive HIV-2- ('HIV-2(+)') and HIV-1-infected ('HIV-1(+)') individuals. Gag-specific responses were detected in the majority of HIV-2(+) and HIV-1(+) subjects. Overlapping...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200526007

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
Pinheiro, S More by this author
Sayeid-Al-Jamee, M More by this author
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Journal:
European journal of immunology
Volume:
35
Issue:
5
Pages:
1445-1453
Publication date:
2005-05-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:065cf5b3-8970-421b-9f2d-da4ecedc95c5
Source identifiers:
664
Local pid:
pubs:664

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