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Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer.

Abstract:

Recent genome-wide association studies (GWASs) have identified common variants at 16 autosomal regions influencing the risk of developing colorectal cancer (CRC). To decipher the genetic basis of the association signals at these loci, we performed a meta-analysis of data from five GWASs, totalling 5626 cases and 7817 controls, using imputation to recover un-typed genotypes. To enhance our ability to discover low-frequency risk variants, in addition to using 1000 Genomes Project data as a refe...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddt357

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Journal:
Human molecular genetics
Volume:
22
Issue:
24
Pages:
5075-5082
Publication date:
2013-12-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:065b7dd2-9703-4cc4-8b0d-07391e656017
Source identifiers:
443553
Local pid:
pubs:443553

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