Journal article icon

Journal article

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer.

Abstract:

Recent genome-wide association studies (GWASs) have identified common variants at 16 autosomal regions influencing the risk of developing colorectal cancer (CRC). To decipher the genetic basis of the association signals at these loci, we performed a meta-analysis of data from five GWASs, totalling 5626 cases and 7817 controls, using imputation to recover un-typed genotypes. To enhance our ability to discover low-frequency risk variants, in addition to using 1000 Genomes Project data as a refe...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/hmg/ddt357

Authors


Expand authors...
Journal:
Human molecular genetics
Volume:
22
Issue:
24
Pages:
5075-5082
Publication date:
2013-12-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
443553
Language:
English
Keywords:
Pubs id:
pubs:443553
UUID:
uuid:065b7dd2-9703-4cc4-8b0d-07391e656017
Local pid:
pubs:443553
Deposit date:
2014-02-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP