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Interleukin-1β maturation triggers its relocation to the plasma membrane for gasdermin-D-dependent and -independent secretion

Abstract:

IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms of IL-1β secretion by pyroptotic and non-pyroptotic cells, and the precise functions of caspase-1 and GSDMD therein, are unresolved. Here, we show that, while efficient early secretion of endogenous IL-1β from primary non-pyroptotic myeloid cells in vitro re...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0003-1441-1727
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Name:
Australian Research Council
More from this funder
Name:
Australian Cancer Research Foundation
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Name:
National Health and Medical Research Council of Australia
More from this funder
Name:
University of Queensland Foundation
Publisher:
Elsevier
Journal:
Cell Reports More from this journal
Volume:
24
Issue:
6
Pages:
1425-1433
Publication date:
2018-08-07
Acceptance date:
2018-07-06
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
30089254
Language:
English
Keywords:
Pubs id:
pubs:896787
UUID:
uuid:065a254d-dc37-4e9b-9f6a-10941f0bb209
Local pid:
pubs:896787
Source identifiers:
896787
Deposit date:
2018-09-03

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