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Journal article

Pinch1 is required for normal development of cranial and cardiac neural crest-derived structures.

Abstract:

Pinch1, an adaptor protein composed of 5 LIM domains, has been suggested to play an important role in multiple cellular processes. We found that Pinch1 is highly expressed in neural crest cells and their derivatives. To examine the requirement for Pinch1 in neural crest development, we generated neural crest conditional Pinch1 knockout mice using the Wnt1-Cre/loxP system. Neural crest conditional Pinch1 mutant embryos die perinatally from severe cardiovascular defects with an unusual aneurysm...

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Publication status:
Published

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Journal:
Circulation research
Volume:
100
Issue:
4
Pages:
527-535
Publication date:
2007-03-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:065513bc-f1fd-48f6-8b9f-228b7f09fd9c
Source identifiers:
110465
Local pid:
pubs:110465

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