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The localization of the target antigens and antibodies in linear IgA disease is heterogeneous, and dependent on the methods used.

Abstract:

Fifty-nine patients with linear IgA disease, 24 with onset in childhood and 35 with adult onset, were studied. Sera from all patients were tested by indirect immunofluorescence, using as substrates intact normal skin and normal skin which had been split through the lamina lucida region of the basement membrane zone by suction and by prolonged incubation with molar NaCl. This enabled the site of the target antigen for the circulating IgA antibodies to be determined. The sites of deposition of ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
British journal of dermatology
Volume:
132
Issue:
5
Pages:
750-757
Publication date:
1995-05-01
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
Source identifiers:
29719

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