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Journal article

A potassium channel β-subunit couples mitochondrial electron transport to sleep

Abstract:

The essential but enigmatic functions of sleep1,2 must be reflected in molecular changes sensed by the brain’s sleep-control systems. In the fruitfly Drosophila, about two dozen sleep-inducing neurons3 with projections to the dorsal fan-shaped body (dFB) adjust their electrical output to sleep need4, via the antagonistic regulation of two potassium conductances: the leak channel Sandman imposes silence during waking, whereas increased A-type curren...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41586-019-1034-5

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Sub department:
Centre for Neural Circuits and Behaviour
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Sub department:
Centre for Neural Circuits and Behaviour
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Sub department:
Centre for Neural Circuits and Behaviour
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Sub department:
Centre for Neural Circuits and Behaviour
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
090309/Z/09/Z
More from this funder
Name:
Gatsby Charitable Foundation
Publisher:
Nature Research
Journal:
Nature More from this journal
Volume:
568
Pages:
230–234
Publication date:
2019-03-20
Acceptance date:
2019-02-19
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pmid:
30894743
Language:
English
Pubs id:
pubs:984001
UUID:
uuid:06545b66-a35f-49ed-a573-2a20374a526d
Local pid:
pubs:984001
Source identifiers:
984001
Deposit date:
2019-04-12

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