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Protease Inhibitor Resistance in the First 3 Years of Second-Line Antiretroviral Therapy for HIV-1 in Sub-Saharan Africa

Abstract:

Background.
As antiretroviral therapy (ART) programs in sub-Saharan Africa mature, increasing numbers of persons with human immunodeficiency virus (HIV) infection will experience treatment failure, and require second- or third-line ART. Data on second-line failure and development of protease inhibitor (PI) resistance in sub-Saharan Africa are scarce.

Methods.
HIV-1–infected adults were included if they received >180 days of PI-based second-line ART. We assessed risk fa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jiw219

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Ministry of Foreign Affairs of the Netherlands More from this funder
Embassy of the Kingdom of the Netherlands More from this funder
Heineken Africa Foundation More from this funder
Jura Foundation More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
214
Issue:
6
Pages:
873-883
Publication date:
2016-07-11
Acceptance date:
2016-05-19
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
699722
Keywords:
Pubs id:
pubs:699722
UUID:
uuid:065438e1-2f79-4667-9265-893404b4d9b6
Local pid:
pubs:699722
Deposit date:
2017-06-19

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