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Parallel synthesis of homochiral beta-amino acids

Abstract:

The parallel asymmetric synthesis of an array of 30 β-amino acids of high enantiomeric purity using the conjugate addition of homochiral lithium N-benzyl-N-(α-methylbenzyl)amide as the key step is accomplished. The experimental simplicity and highly practical nature of the protocol is demonstrated by the efficient parallel conversion of 15 α,β-unsaturated esters to both enantiomeric series of the corresponding β-amino acids in high overall yields and selectivities with minimal purification in...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Mulvaney, AW More by this author
Russell, AJ More by this author
Journal:
TETRAHEDRON-ASYMMETRY
Volume:
18
Issue:
13
Pages:
1554-1566
Publication date:
2007-07-17
DOI:
EISSN:
1362-511X
ISSN:
0957-4166
URN:
uuid:0653686d-b6bf-4df0-8b4b-28297d312ab7
Source identifiers:
40494
Local pid:
pubs:40494
Language:
English

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