Parallel synthesis of homochiral beta-amino acids

Journal article

The parallel asymmetric synthesis of an array of 30 β-amino acids of high enantiomeric purity using the conjugate addition of homochiral lithium N-benzyl-N-(α-methylbenzyl)amide as the key step is accomplished. The experimental simplicity and highly practical nature of the protocol is demonstrated by the efficient parallel conversion of 15 α,β-unsaturated esters to both enantiomeric series of the corresponding β-amino acids in high overall yields and selectivities with minimal purification involved in each step of the reaction protocol. © 2007 Elsevier Ltd. All rights reserved.

Authors: Davies, S; Mulvaney, A; Russell, A; Smith, A

• Publication status: Published
• Journal: TETRAHEDRON-ASYMMETRY
• Volume: 18
• Issue: 13
• Pages: 1554-1566
• Publication date: 2007-07-17
• DOI: 10.1016/j.tetasy.2007.06.008
• EISSN: 1362-511X
• ISSN: 0957-4166
• Language: English