Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.

Journal article

It is of pivotal importance for genome stability that repair DNA polymerases (Pols), such as Pols λ and β, which all exhibit considerably reduced fidelity when replicating undamaged DNA, are tightly regulated, because their misregulation could lead to mutagenesis. Recently, we found that the correct repair of the abundant and highly miscoding oxidative DNA lesion 7,8-dihydro-8-oxo-2'-deoxyguanine (8-oxo-G) is performed by an accurate repair pathway that is coordinated by the MutY glycosylase ...

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Authors: Markkanen, E; van Loon, B; Ferrari, E; Parsons, J; Dianov, G

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 109
• Issue: 2
• Pages: 437-442
• Publication date: 2012-01-01
• DOI: 10.1073/pnas.1110449109
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Hydrogen Peroxide; Humans; Oligonucleotides; RNA Interference; DNA Repair; Deoxyguanosine; Reverse Transcriptase Polymerase Chain Reaction; Ubiquitination; Hela Cells; DNA Glycosylases; DNA Damage; Phosphorylation; Blotting, Western; Ubiquitin-Protein Ligases; Oxidation-Reduction; DNA Polymerase beta