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Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.

Abstract:

Cardiac hypertrophy is a growth response of the heart to increased hemodynamic demand or damage. Accompanying this heart enlargement is a remodeling of Ca(2+) signaling. Due to its fundamental role in controlling cardiomyocyte contraction during every heartbeat, modifications in Ca(2+) fluxes significantly impact on cardiac output and facilitate the development of arrhythmias. Using cardiomyocytes from spontaneously hypertensive rats (SHRs), we demonstrate that an increase in Ca(2+) release t...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0905485106

Authors


Harzheim, D More by this author
Movassagh, M More by this author
Tashfeen, A More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
27
Pages:
11406-11411
Publication date:
2009-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:064ab53c-e5df-4203-ab7e-2b784570ceac
Source identifiers:
41294
Local pid:
pubs:41294

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