Journal article
Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.
- Abstract:
-
Cardiac hypertrophy is a growth response of the heart to increased hemodynamic demand or damage. Accompanying this heart enlargement is a remodeling of Ca(2+) signaling. Due to its fundamental role in controlling cardiomyocyte contraction during every heartbeat, modifications in Ca(2+) fluxes significantly impact on cardiac output and facilitate the development of arrhythmias. Using cardiomyocytes from spontaneously hypertensive rats (SHRs), we demonstrate that an increase in Ca(2+) release t...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.0905485106
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 106
- Issue:
- 27
- Pages:
- 11406-11411
- Publication date:
- 2009-07-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:064ab53c-e5df-4203-ab7e-2b784570ceac
- Source identifiers:
-
41294
- Local pid:
- pubs:41294
Item Description
Terms of use
- Copyright date:
- 2009
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