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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Abstract:

Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide association study (TWAS) for PrCa. We identify 217 genes at 84 independent 1 Mb regions associated with PrCa risk, 9 of wh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-06302-1

Authors


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Role:
Author
ORCID:
0000-0002-9352-5927
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Role:
Author
ORCID:
0000-0002-7980-4620
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Role:
Author
ORCID:
0000-0003-1226-070X
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Name:
NHGRI NIH HHS
Grant:
R01 HG009120
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Name:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
Grant:
U01-CA194393
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Name:
U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI)
Grant:
R01-HG006399
R01-HG009120
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Name:
Cancer Research UK
Grant:
16491
18504
Publisher:
Springer
Journal:
Nature Communications More from this journal
Volume:
9
Issue:
1
Article number:
4079
Publication date:
2018-10-04
Acceptance date:
2018-08-28
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
30287866
Language:
English
Keywords:
Pubs id:
pubs:928759
UUID:
uuid:06490253-3de5-410d-92ca-6daf03862642
Local pid:
pubs:928759
Source identifiers:
928759
Deposit date:
2019-03-14

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