Journal article
Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
- Abstract:
-
Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide association study (TWAS) for PrCa. We identify 217 genes at 84 independent 1 Mb regions associated with PrCa risk, 9 of wh...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 912.3KB)
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(Version of record, pdf, 386.6KB)
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- Publisher copy:
- 10.1038/s41467-018-06302-1
Authors
Funding
Bibliographic Details
- Publisher:
- Springer Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 9
- Issue:
- 1
- Article number:
- 4079
- Publication date:
- 2018-10-04
- Acceptance date:
- 2018-08-28
- DOI:
- EISSN:
-
2041-1723
- ISSN:
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2041-1723
- Pmid:
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30287866
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:928759
- UUID:
-
uuid:06490253-3de5-410d-92ca-6daf03862642
- Local pid:
- pubs:928759
- Source identifiers:
-
928759
- Deposit date:
- 2019-03-14
Terms of use
- Copyright holder:
- Nicholas et al
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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