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BCR repertoire sequencing: different patterns of B cell activation after two Meningococcal vaccines.

Abstract:

Next-generation sequencing was used to investigate the B cell receptor heavy chain transcript repertoire of different B cell subsets (naïve, marginal zone, IgM memory and IgG memory) at baseline, and of plasma cells 7 days following administration of serogroup ACWY meningococcal polysaccharide and protein-polysaccharide conjugate vaccines. Baseline B cell subsets could be distinguished from each other using a small number of repertoire properties (clonality, mutation from germ-line and comple...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/icb.2015.57

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Funding agency for:
Cerundolo, V
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Funding agency for:
Pollard, A
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Funding agency for:
Galson, J
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
93
Pages:
885–895
Publication date:
2015-06-01
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Source identifiers:
523145
Language:
English
Pubs id:
pubs:523145
UUID:
uuid:06439bbb-5cb2-4f6a-b448-bc24086b4bc8
Local pid:
pubs:523145
Deposit date:
2015-11-28

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