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BCR repertoire sequencing: different patterns of B cell activation after two Meningococcal vaccines.

Abstract:

Next-generation sequencing was used to investigate the B cell receptor heavy chain transcript repertoire of different B cell subsets (naïve, marginal zone, IgM memory and IgG memory) at baseline, and of plasma cells 7 days following administration of serogroup ACWY meningococcal polysaccharide and protein-polysaccharide conjugate vaccines. Baseline B cell subsets could be distinguished from each other using a small number of repertoire properties (clonality, mutation from germ-line and comple...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Wellcome Trust Centre for Human Genetics More from this funder
Nuffield Department of Medicine More from this funder
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Grant:
Funding agency for:
Pollard, A
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
93
Pages:
885–895
Publication date:
2015-06-01
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Pubs id:
pubs:523145
UUID:
uuid:06439bbb-5cb2-4f6a-b448-bc24086b4bc8
Source identifiers:
523145
Local pid:
pubs:523145
Language:
English

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