- Abstract:
-
Next-generation sequencing was used to investigate the B cell receptor heavy chain transcript repertoire of different B cell subsets (naïve, marginal zone, IgM memory and IgG memory) at baseline, and of plasma cells 7 days following administration of serogroup ACWY meningococcal polysaccharide and protein-polysaccharide conjugate vaccines. Baseline B cell subsets could be distinguished from each other using a small number of repertoire properties (clonality, mutation from germ-line and comple...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
- Publisher copy:
- 10.1038/icb.2015.57
-
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- Grant:
- Funding agency for:
- Kelly, D
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Immunology and Cell Biology Journal website
- Volume:
- 93
- Pages:
- 885–895
- Publication date:
- 2015-06-01
- DOI:
- EISSN:
-
1440-1711
- ISSN:
-
0818-9641
- Pubs id:
-
pubs:523145
- UUID:
-
uuid:06439bbb-5cb2-4f6a-b448-bc24086b4bc8
- Source identifiers:
-
523145
- Local pid:
- pubs:523145
- Language:
- English
- Copyright holder:
- Australasian Society for Immunology Inc
- Notes:
- Copyright © 2015 Australasian Society for Immunology Inc.
Journal article
BCR repertoire sequencing: different patterns of B cell activation after two Meningococcal vaccines.
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+ National Institute for Health Research Oxford Biomedical Research Centre
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National Institute for Health Research Oxford Biomedical Research Centre
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Wellcome Trust Centre for Human Genetics
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Nuffield Department of Medicine
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