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Association of caveolin-1 gene polymorphism with kidney transplant fibrosis and allograft failure.

Abstract:

CONTEXT: Caveolin-1 (CAV1) is an inhibitor of tissue fibrosis. OBJECTIVE: To study the association of CAV1 gene variation with kidney transplant outcome, using kidney transplantation as a model of accelerated fibrosis. DESIGN, SETTING, AND PATIENTS: Candidate gene association and validation study. Genomic DNA from 785 white kidney transplant donors and their respective recipients (transplantations in Birmingham, England, between 1996 and 2006; median follow-up, 81 months) were analyzed for co...

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Publisher copy:
10.1001/jama.2010.356

Authors


McKnight, AJ More by this author
Simmonds, MJ More by this author
Courtney, AE More by this author
Hanvesakul, R More by this author
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Journal:
JAMA
Volume:
303
Issue:
13
Pages:
1282-1287
Publication date:
2010-04-05
DOI:
EISSN:
1538-3598
ISSN:
0098-7484
URN:
uuid:064228af-d247-47e1-84df-8ecb7bdf9c7f
Source identifiers:
176425
Local pid:
pubs:176425

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