A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.

Journal article

The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dyna...

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Authors: Kamieniarz, K; Izzo, A; Dundr, M; Tropberger, P; Ozretic, L

• Journal: Genes and development
• Volume: 26
• Issue: 8
• Pages: 797-802
• Publication date: 2012-04-01
• DOI: 10.1101/gad.182014.111
• EISSN: 1549-5477
• ISSN: 0890-9369
• Language: English
• Keywords: Histones; Transcription Initiation Site; Testicular Neoplasms; Promoter Regions, Genetic; Acetylation; Molecular Sequence Data; TATA-Binding Protein Associated Factors; Lysine; Male; Pluripotent Stem Cells; Transcription Factor TFIID; Spermatogenesis; Cell Cycle; Humans; Up-Regulation; Amino Acid Sequence; p300-CBP Transcription Factors; Seminoma; Gene Expression Regulation, Neoplastic; Transcriptional Activation