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Experimental treatment of Ebola virus disease with brincidofovir

Abstract:

The nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health Organisation list of agents that should be prioritised for clinical evaluation in patients with Ebola virus disease (EVD) during the West African epidemic.In this single-arm phase 2 trial conducted in Liberia, patients with laboratory-confirmed EVD (tw...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
More from this funder
Name:
European Commission
Grant:
EU FP7 project PREPARE (602525
More from this funder
Name:
Wellcome Trust
Grant:
106491/Z/14/Z
089275/Z/09/Z
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
11
Issue:
9
Article number:
e0162199
Publication date:
2016-09-09
Acceptance date:
2016-08-15
DOI:
ISSN:
1932-6203
Pmid:
27611077
Language:
English
Keywords:
Pubs id:
pubs:642047
UUID:
uuid:06380110-4ad0-45f7-b34b-0278b28213dd
Local pid:
pubs:642047
Source identifiers:
642047
Deposit date:
2017-08-17

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