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Experimental treatment of Ebola virus disease with brincidofovir

Abstract:

The nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health Organisation list of agents that should be prioritised for clinical evaluation in patients with Ebola virus disease (EVD) during the West African epidemic.In this single-arm phase 2 trial conducted in Liberia, patients with laboratory-confirmed EVD (tw...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0162199

Authors


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Department:
Oxford, MSD, NDM, Tropical Medicine
Kennedy, SB More by this author
Antierens, A More by this author
Whitehead, J More by this author
Ciglenecki, I More by this author
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Grant:
106491/ Z/14/Z and 089275/Z/09/Z
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Grant:
EU FP7 project PREPARE (602525)
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
11
Issue:
9
Pages:
Article: e0162199
Publication date:
2016-09-09
DOI:
ISSN:
1932-6203
Pubs id:
pubs:642047
URN:
uri:06380110-4ad0-45f7-b34b-0278b28213dd
UUID:
uuid:06380110-4ad0-45f7-b34b-0278b28213dd
Local pid:
pubs:642047
Language:
English
Keywords:

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