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Differences in outcome according to Clostridium difficile testing method: A prospective multicentre diagnostic validation study of C difficile infection

Abstract:

Background: Diagnosis of Clostridium difficile infection is controversial because of many laboratory methods, compounded by two reference methods. Cytotoxigenic culture detects toxigenic C difficile and gives a positive result more frequently (eg, because of colonisation, which means that individuals can have the bacterium but no free toxin) than does the cytotoxin assay, which detects preformed toxin in faeces. We aimed to validate the reference methods according to clinical outcomes and to ...

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Journal:
Lancet Infectious Diseases More from this journal
Volume:
13
Issue:
11
Pages:
936-945
Publication date:
2013-11-01
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Language:
English
Pubs id:
pubs:436397
UUID:
uuid:0633f78b-c696-4baa-b2ff-a889df0e8bb6
Local pid:
pubs:436397
Source identifiers:
436397
Deposit date:
2013-11-16

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