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Biological therapies for asthma

Abstract:

Five to 10% of asthma patients remain symptomatic and/or have asthma attacks despite adequate inhaled and systemic therapy. Eosinophilic, type 2 airway inflammation is seen in half of these patients with severe asthma. There is now convincing evidence that type 2 inflammation drives susceptibility to asthma attacks and is associated with a good response to biological therapies. Monoclonal antibodies targeting immunoglobulin E, interleukin (IL)-5 and IL-4/13 now have established efficacy in se...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Kellogg College
Role:
Author

Contributors

Role:
Editor
Publisher:
Elsevier Publisher's website
Pages:
411-434
Host title:
Encyclopedia of Respiratory Medicine
Publication date:
2021-09-17
DOI:
ISBN:
978-0-08-102724-0
Language:
English
Keywords:
Subtype:
Chapter
Pubs id:
1185472
Local pid:
pubs:1185472
Deposit date:
2021-07-09

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