Book section : Chapter

Biological therapies for asthma

Abstract:: Five to 10% of asthma patients remain symptomatic and/or have asthma attacks despite adequate inhaled and systemic therapy. Eosinophilic, type 2 airway inflammation is seen in half of these patients with severe asthma. There is now convincing evidence that type 2 inflammation drives susceptibility to asthma attacks and is associated with a good response to biological therapies. Monoclonal antibodies targeting immunoglobulin E, interleukin (IL)-5 and IL-4/13 now have established efficacy in severe type 2 asthma. Novel alarmin-blocking and crystal-dissolving therapies are promising. Prescribing biologics, weaning steroids and treating subsequent exacerbations are rapidly evolving clinical challenges.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Couillard Castonguay, S., & Pavord, I. (2021). Biological therapies for asthma. In S. Janes (Ed.), Encyclopedia of Respiratory Medicine (2nd ed., pp. 411–434). Elsevier.

MLA Style

Couillard Castonguay, S., and I. Pavord. “Biological Therapies for Asthma.” Encyclopedia of Respiratory Medicine, edited by S Janes, 2nd ed., Elsevier, 2021, pp. 411–34.

Chicago Style

Couillard Castonguay, S, and I Pavord. 2021. “Biological Therapies for Asthma.” In Encyclopedia of Respiratory Medicine, edited by S Janes, 2nd ed., 411–34. Elsevier.
Share
Print

Access Document

Publisher copy:: 10.1016/B978-0-08-102723-3.00071-8

Authors

+ Couillard Castonguay, S More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: NDM Experimental Medicine
Oxford college:: Kellogg College
Role:: Author

+ Pavord, I More by this author

Role:: Author

Contributors

Role:: Editor

Publisher:: Elsevier
Host title:: Encyclopedia of Respiratory Medicine
Pages:: 411-434
Publication date:: 2021-09-17
Edition:: 2nd
DOI:: 10.1016/B978-0-08-102723-3.00071-8
ISBN:: 978-0-08-102724-0

Language:: English
Keywords:: biomarkers

FFR

FeNO

airways

multidisciplinary team

exacerbations

asthma

adherence

eosinophils

severe asthma

type-2 inflammation

biologics
Subtype:: Chapter
Pubs id:: 1185472
Local pid:: pubs:1185472
Deposit date:: 2021-07-09

Terms of use

Copyright holder:: Elsevier.
Copyright date:: 2021
Rights statement:: © 2022 Elsevier Ltd. All rights reserved

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP