Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.

Journal article

The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention of mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) T-cell responses restricted by two closely related HLA class I alleles, B*5701 and B*5703, that differ by two amino acids but are both associated with a dominant response to the same HIV-1 Gag epitope KF11 (KAFSPEVIPMF). When this epitope is presented by HLA-B*5701, it induces a TCR reperto...

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Authors: Yu, X; Lichterfeld, M; Chetty, S; Williams, K; Mui, S

• Publication status: Published
• Journal: Journal of virology
• Volume: 81
• Issue: 4
• Pages: 1619-1631
• Publication date: 2007-02-01
• DOI: 10.1128/jvi.01580-06
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Immunodominant Epitopes; Species Specificity; Gene Products, gag; Amino Acid Substitution; Epitopes, T-Lymphocyte; Alleles; HIV-1; Histocompatibility Antigens Class I; HIV Infections; Receptors, Antigen, T-Cell; CD8-Positive T-Lymphocytes; Humans; Mutation