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2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor

Abstract:

T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated Ca2+ entry (SOCE), one of the essential signals for T cell activation. Recently, the steroidal 2-methoxyestradiol was shown to inhibit nuclear translocation of the nuclear factor of activated T cells (NFAT). We therefore investigated 2-methoxyestradiol for inhibition of Ca2+ e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbamcr.2021.118988

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Name:
Wellcome Trust
Grant:
101010/B/13/Z
Publisher:
Elsevier
Journal:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research More from this journal
Volume:
1868
Issue:
6
Article number:
118988
Publication date:
2021-02-10
Acceptance date:
2021-02-04
DOI:
EISSN:
1879-2596
ISSN:
0167-4889
Pmid:
33581218
Language:
English
Keywords:
Pubs id:
1162118
Local pid:
pubs:1162118
Deposit date:
2021-04-27

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