Journal article
2-Methoxyestradiol and its derivatives inhibit store-operated Ca2+ entry in T cells: identification of a new and potent inhibitor
- Abstract:
-
T cell activation starts with formation of second messengers that release Ca2+ from the endoplasmic reticulum (ER) and thereby activate store-operated Ca2+ entry (SOCE), one of the essential signals for T cell activation. Recently, the steroidal 2-methoxyestradiol was shown to inhibit nuclear translocation of the nuclear factor of activated T cells (NFAT). We therefore investigated 2-methoxyestradiol for inhibition of Ca2+ e...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Journal website
- Volume:
- 1868
- Issue:
- 6
- Article number:
- 118988
- Publication date:
- 2021-02-10
- Acceptance date:
- 2021-02-04
- DOI:
- EISSN:
-
1879-2596
- ISSN:
-
0167-4889
- Pmid:
-
33581218
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1162118
- Local pid:
- pubs:1162118
- Deposit date:
- 2021-04-27
Terms of use
- Copyright holder:
- L¨ohndorf et al.
- Copyright date:
- 2021
- Rights statement:
- ©2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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