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Abeta amyloid deposition in the language system and how the brain responds.

Abstract:

Post-mortem measures of Abeta amyloid deposition correlate only weakly with cognitive dysfunction antemortem. We tested the hypothesis that functional reorganization forms a critical intermediary step between Abeta amyloid-associated brain injury and clinical disease expression. Fifteen patients with early-stage probable Alzheimer's disease (AD) and 16 cognitively intact controls participated in this combined functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) ...

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Publisher copy:
10.1093/brain/awm133

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Vandenbulcke, M More by this author
Verbruggen, A More by this author
Peeters, R More by this author
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Journal:
Brain : a journal of neurology
Volume:
130
Issue:
Pt 8
Pages:
2055-2069
Publication date:
2007-08-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:06241f22-cc21-4980-b0b4-c8c27c810f76
Source identifiers:
429457
Local pid:
pubs:429457

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