Neurotoxic lesions of ventrolateral but not anteromedial neostriatum in rats impair differential reinforcement of low rates (DRL) performance.

Journal article

In two separate experiments, rats received either kainic acid (KA), 6-hydroxydopamine (6-OHDA) or control lesions bilaterally into either the anteromedial or ventrolateral neostriatum. Both ventrolateral neurotoxic lesions disrupted post-operative body weight regulation and the acquisition of a DRL-20 sec operant schedule of reinforcement. The pattern of operant responding suggested that these animals had an impairment in response sequencing or switching. Rats with anteromedial lesions manifested neither body-weight nor DRL impairments.

Authors: Dunnett, S; Iversen, S

• Publication status: Published
• Journal: Behavioural brain research
• Volume: 6
• Issue: 3
• Pages: 213-226
• Publication date: 1982-11-01
• DOI: 10.1016/0166-4328(82)90024-9
• EISSN: 1872-7549
• ISSN: 0166-4328
• Language: English
• Keywords: Putamen; Caudate Nucleus; Animals; Mental Recall; Afferent Pathways; Rats; Male; Kainic Acid; Frontal Lobe; Corpus Striatum; Conditioning, Operant; Reinforcement Schedule; Rats, Inbred Strains; Brain Mapping; Oxidopamine; Hydroxydopamines