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Neurotoxic lesions of ventrolateral but not anteromedial neostriatum in rats impair differential reinforcement of low rates (DRL) performance.

Abstract:
In two separate experiments, rats received either kainic acid (KA), 6-hydroxydopamine (6-OHDA) or control lesions bilaterally into either the anteromedial or ventrolateral neostriatum. Both ventrolateral neurotoxic lesions disrupted post-operative body weight regulation and the acquisition of a DRL-20 sec operant schedule of reinforcement. The pattern of operant responding suggested that these animals had an impairment in response sequencing or switching. Rats with anteromedial lesions manifested neither body-weight nor DRL impairments.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Behavioural brain research
Volume:
6
Issue:
3
Pages:
213-226
Publication date:
1982-11-05
DOI:
EISSN:
1872-7549
ISSN:
0166-4328
URN:
uuid:061b3e94-4cbb-4eeb-9b6c-54a90e1163d7
Source identifiers:
30655
Local pid:
pubs:30655

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