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Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.

Abstract:

Previously we have shown that the imino sugar inhibitor of N-linked glycan processing, N-nonyl-deoxynojirimycin (N-nonyl-DNJ), had antiviral activity in the woodchuck model of chronic hepatitis B virus (HBV) infection. In studying the mechanism of action of this compound, it was discovered that imino sugars could inhibit HBV secretion without inhibiting N-linked glycoprocessing. Although N-nonyl-DNJ is an inhibitor of the endoplasmic reticulum (ER) glucosidase, here it is shown that N-nonyl-D...

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Publication status:
Published

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Publisher copy:
10.1053/jhep.2001.25103

Authors


Carrouée, S More by this author
Conyers, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Journal:
Hepatology (Baltimore, Md.)
Volume:
33
Issue:
6
Pages:
1488-1495
Publication date:
2001-06-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:0616aaf0-bd8b-4ccf-bd63-b945731a0e29
Source identifiers:
100516
Local pid:
pubs:100516

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