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Interleukin-1 beta and interleukin-6 specifically increase the release of prostaglandin E2 from rat hypothalamic explants in vitro.

Abstract:

It has previously been shown that the cytokines interleukin-1 beta and interleukin-6 (IL-1 beta and IL-6) stimulate directly the release of corticotrophin-releasing-hormone-41 from the rat hypothalamus in vitro, while IL-1 beta can also stimulate the release of somatostatin. These effects can be antagonized by drugs which block prostaglandin (PG) synthesis. PGs are also involved in the control of hypothalamic neuropeptides by other neurotransmitters. In the present study, we have characterize...

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Publication status:
Published

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Publisher copy:
10.1159/000126209

Authors


Navarra, P More by this author
Pozzoli, G More by this author
Brunetti, L More by this author
Ragazzoni, E More by this author
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Journal:
Neuroendocrinology
Volume:
56
Issue:
1
Pages:
61-68
Publication date:
1992-07-05
DOI:
EISSN:
1423-0194
ISSN:
0028-3835
URN:
uuid:0614bfbd-bc8e-440e-b6fc-ca39c6461908
Source identifiers:
138497
Local pid:
pubs:138497

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