Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals.

Siasos, G; Tousoulis, D; Vlachopoulos, C; Antoniades, C; Stefanadi, E; Ioakeimidis, N; Andreou, I; Zisimos, K; Papavassiliou, A; Stefanadis, C

Journal article

Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals.

Abstract:: BACKGROUND: L-arginine, the substrate for endothelial nitric oxide synthase, is essential for normal endothelial function. Aim of the present study was to investigate in healthy smokers the effect of a short-term daily L-arginine administration on vascular function. METHODS: We studied the effect of a 3-day oral administration of L-arginine in 10 healthy smokers (24.3+/-0.73 years old) on 3 occasions (day , day 1 and day 3). The study was carried out on two separate arms, one with L-arginine (7 gr/d) and one with placebo according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before, immediately after (Sm0) and 20 min after (Sm20) cigarette smoking. Endothelial function was evaluated by flow-mediated dilatation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. RESULTS: Compared to placebo, L-arginine led to an increase of FMD (p<0.05 at day 2), indicating a favorable effect on endothelial function, which however lost significance at day 3. l-arginine induced a progressive decrease of PWV and AIx at both day 2 and day 3 (p<0.01 vs baseline for all). L-arginine blunted the acute smoking-induced increase of AIx at both day 1 (p<0.05) and day 3 (p<0.01), and there was a trend to protect the smoking-induced change of PWV at day 3 (p<0.1). CONCLUSIONS: Short-term daily administration of L-arginine improves arterial performance in healthy smokers and abrogates the smoking-induced increase in arterial stiffness and wave reflections in these individuals.

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APA Style

Siasos, G., Tousoulis, D., Vlachopoulos, C., Antoniades, C., Stefanadi, E., Ioakeimidis, N., Andreou, I., Zisimos, K., Papavassiliou, A., & Stefanadis, C. (2008). Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals. International Journal of Cardiology, 126(3), 394–399.

MLA Style

Siasos, G, et al. “Short-Term Treatment with L-Arginine Prevents the Smoking-Induced Impairment of Endothelial Function and Vascular Elastic Properties in Young Individuals.” International Journal of Cardiology, vol. 126, no. 3, 2008, pp. 394–99.

Chicago Style

Siasos, G, D Tousoulis, C Vlachopoulos, et al. 2008. “Short-Term Treatment with L-Arginine Prevents the Smoking-Induced Impairment of Endothelial Function and Vascular Elastic Properties in Young Individuals.” International Journal of Cardiology 126 (3): 394–99.
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