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Common filaggrin null alleles are not associated with hymenoptera venom allergy in Europeans.

Abstract:

The association of filaggrin mutations with atopic eczema (atopic dermatitis, AD) is well established and it is thought that filaggrin dysfunction impairs the skin's barrier function allowing allergen penetration and subsequent cutaneous sensitisation and inflammation. However, as most forms of barrier dysfunction are not associated with allergic sensitisation to common allergens, the possibility that filaggrin itself is involved in Th1/Th2 polarisation remains. We tested the hypothesis that ...

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Publication status:
Published

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Publisher copy:
10.1159/000321829
Journal:
International archives of allergy and immunology More from this journal
Volume:
154
Issue:
4
Pages:
353-355
Publication date:
2011-01-01
DOI:
EISSN:
1423-0097
ISSN:
1018-2438
Language:
English
Keywords:
Pubs id:
pubs:90822
UUID:
uuid:0612a05f-3f08-4728-834a-f045e05839cf
Local pid:
pubs:90822
Source identifiers:
90822
Deposit date:
2012-12-19

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