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Journal article

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.

Abstract:

The influence of the antidiabetic sulphonylurea tolbutamide on K+ channels of mouse pancreatic beta-cells was investigated using different configurations of the patch clamp technique. The dominant channel in resting cells is a K+ channel with a single-channel conductance of 60 pS that is inhibited by intracellular ATP or, in intact cells, by stimulation with glucose. In isolated patches of beta-cells membrane, this channel was blocked by tolbutamide (0.1 mM) when applied to either the intrace...

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Publication status:
Published

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Publisher copy:
10.1007/bf00657506

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Publisher:
Springer-Verlag
Journal:
Pflugers Archiv : European journal of physiology
Volume:
407
Issue:
5
Pages:
493-499
Publication date:
1986-11-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:060d2380-9d60-4480-a1a7-1141f4d3d1bd
Source identifiers:
11324
Local pid:
pubs:11324

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