Journal article
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.
- Abstract:
-
The influence of the antidiabetic sulphonylurea tolbutamide on K+ channels of mouse pancreatic beta-cells was investigated using different configurations of the patch clamp technique. The dominant channel in resting cells is a K+ channel with a single-channel conductance of 60 pS that is inhibited by intracellular ATP or, in intact cells, by stimulation with glucose. In isolated patches of beta-cells membrane, this channel was blocked by tolbutamide (0.1 mM) when applied to either the intrace...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/bf00657506
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Bibliographic Details
- Publisher:
- Springer-Verlag
- Journal:
- Pflugers Archiv : European journal of physiology
- Volume:
- 407
- Issue:
- 5
- Pages:
- 493-499
- Publication date:
- 1986-11-01
- DOI:
- EISSN:
-
1432-2013
- ISSN:
-
0031-6768
- Source identifiers:
-
11324
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:11324
- UUID:
-
uuid:060d2380-9d60-4480-a1a7-1141f4d3d1bd
- Local pid:
- pubs:11324
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1986
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