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Systemic administration of 8-OH-DPAT and eticlopride, but not SCH23390, alters loss-chasing behavior in the rat.

Abstract:

Gambling to recover losses is a common gaming behavior. In a clinical context, however, this phenomenon mediates the relationship between diminished control over gambling and the adverse socioeconomic consequences of gambling problems. Modeling loss-chasing through analogous behaviors in rats could facilitate its pharmacological investigation as a potential therapeutic target. Here, rats were trained to make operant responses that produced both food rewards, and unpredictably, imminent time-o...

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Publication status:
Published

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Publisher copy:
10.1038/npp.2013.8

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume:
38
Issue:
6
Pages:
1094-1104
Publication date:
2013-05-05
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:060d083a-809e-4e7b-b374-c133673dc521
Source identifiers:
374283
Local pid:
pubs:374283

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