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Human bone marrow organoids for disease modelling, discovery and validation of therapeutic targets in hematological malignancies

Abstract:

A lack of models that recapitulate the complexity of human bone marrow has hampered mechanistic studies of normal and malignant hematopoiesis and the validation of novel therapies. Here, we describe a step-wise, directed-differentiation protocol in which organoids are generated from induced pluripotent stem cells committed to mesenchymal, endothelial, and hematopoietic lineages. These 3D structures capture key features of human bone marrow—stroma, lumen-forming sinusoids, and myeloid cells in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/2159-8290.cd-22-0199

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Role:
Author
ORCID:
0000-0003-0825-3179
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Role:
Author
ORCID:
0000-0001-7193-9144
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Role:
Author
ORCID:
0000-0002-0980-6663
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Role:
Author
ORCID:
0000-0003-2252-1424
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Name:
Wellcome Trust
Grant:
216632/Z/19/Z
Publisher:
American Association for Cancer Research
Journal:
Cancer Discovery More from this journal
Volume:
13
Issue:
2
Pages:
364-385
Publication date:
2023-02-06
Acceptance date:
2022-11-07
DOI:
EISSN:
2159-8290
ISSN:
2159-8274
Language:
English
Keywords:
Pubs id:
1300971
Local pid:
pubs:1300971
Deposit date:
2022-11-10

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