Isolation of cytomegalovirus-specific cytotoxic T-lymphocytes from gut-associated lymphoid tissue (GALT) of HIV type 1-infected subjects.

Journal article

Cytomegalovirus (CMV) can be an important opportunistic infection in HIV-1-infected patients, particularly when the CD4+ T-cell count drops below 50 lymphocytes/mm3. CMV-associated disease, including retinitis, pneumonitis, gastroenteritis, and encephalitis, is estimated to affect up to 40% of AIDS patients. We have studied the cellular immune response to CMV in gut-associated lymphoid tissue (GALT) of HIV-1-infected patients. Two patients with chronic diarrhea of unknown etiology were examin...

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Authors: Shacklett, B; Beadle, T; Pacheco, P; Grendell, J; Haslett, P

• Publication status: Published
• Journal: AIDS research and human retroviruses
• Volume: 16
• Issue: 12
• Pages: 1157-1162
• Publication date: 2000-08-01
• DOI: 10.1089/088922200415009
• EISSN: 1931-8405
• ISSN: 0889-2229
• Language: English
• Keywords: Rectum; Male; Humans; Acquired Immunodeficiency Syndrome; Antigens, CD; T-Lymphocytes, Cytotoxic; Middle Aged; Lymphocyte Activation; HIV Infections; Immunophenotyping; Lymphoid Tissue; Intestinal Mucosa; Cytotoxicity, Immunologic; Duodenum