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Dominant transplantation tolerance. Opinion.

Abstract:
Long-term allograft survival in the absence of continuous immunosuppression can be induced following a short treatment of nondepleting antibodies, such as those that target CD4 or CD154 (CD40 ligand). It is now established that this may involve dominant tolerance mechanisms that are maintained by CD4+ regulatory T cells present within the lymphoid tissue and the tolerated graft. The phenotype of these cells, their relationship to CD4+CD25+ T cells, and the mechanism of action are still controversial.
Publication status:
Published

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Authors


Le Moine, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Current opinion in immunology
Volume:
15
Issue:
5
Pages:
499-506
Publication date:
2003-10-05
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
URN:
uuid:0607876f-f977-4c54-922a-6e1580fa0641
Source identifiers:
30760
Local pid:
pubs:30760

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