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Mechanism of diol dehydration by a promiscuous radical‐SAM enzyme homologue of the antiviral enzyme viperin (RSAD2)

Abstract:

3´‐deoxy nucleotides are an important class of drugs because they interfere with metabolism of nucleotides and their incorporation into DNA or RNA terminates cell division and viral replication. These compounds have largely been produced via multistep chemical synthesis and an enzyme with the ability to catalyse removal of 3´‐deoxy group from different nucleotides has yet to be described. Here, using a combination of HPLC, high‐resolution mass spectrometry, and NMR spectroscopy we demonstrate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/cbic.201900776

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Brasenose College
Role:
Author
ORCID:
0000-0002-2506-1198
Publisher:
Wiley
Journal:
ChemBioChem More from this journal
Volume:
21
Issue:
11
Pages:
1605-1612
Publication date:
2020-02-27
Acceptance date:
2020-01-17
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
Language:
English
Keywords:
Pubs id:
pubs:1083236
UUID:
uuid:06047fd8-cbe5-497d-83ca-7bb146fdbc95
Local pid:
pubs:1083236
Source identifiers:
1083236
Deposit date:
2020-01-20

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