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Using MRI to measure drug action: caveats and new directions.

Abstract:

Investigating pharmacological modulation of brain activity using magnetic resonance imaging (MRI) presents an exciting opportunity to bridge the gap between preclinical and clinical studies, and holds the potential to be a useful tool in the discovery and development of novel therapeutic agents. Most functional MRI studies to date have utilized the blood oxygen level dependent (BOLD) contrast mechanism. Although this has some advantages over other techniques and is widely available, BOLD has ...

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Publication status:
Published

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Publisher copy:
10.1177/0269881110372547

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
Journal of psychopharmacology (Oxford, England) More from this journal
Volume:
25
Issue:
9
Pages:
1168-1174
Publication date:
2011-09-01
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
Language:
English
Keywords:
Pubs id:
pubs:186509
UUID:
uuid:05ff6787-d58c-40d6-8c30-e9c1b8fd2782
Local pid:
pubs:186509
Source identifiers:
186509
Deposit date:
2012-12-19

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