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Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection.

Abstract:

While a significant proportion of HIV-2-infected individuals are asymptomatic and maintain undetectable viral loads (controllers), 15% to 20% progress to AIDS and are predicted by detectable viremia. Identifying immune correlates that distinguish these 2 groups should provide insights into how a potentially pathogenic retrovirus can be naturally controlled. We performed a detailed study of HIV-2-specific cellular responses in a unique community cohort in Guinea-Bissau followed for over 2 deca...

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Publication status:
Published

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Journal:
Blood
Volume:
121
Issue:
21
Pages:
4330-4339
Publication date:
2013-05-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
394893

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