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Journal article

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.

Abstract:

OBJECTIVE: Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an optimal but not excessive level of Wnt activation is considered favourable for tumourigenesis. The authors assessed effects of pan-intestinal Wnt activation on tissue homeostasis, taking into account underlying physiological Wnt activity and stem-cell number in each region of the bowel. DESIGN: The authors generated mice tha...

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Publication status:
Published

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Publisher copy:
10.1136/gutjnl-2011-301601

Authors


Leedham, SJ More by this author
Rodenas-Cuadrado, P More by this author
Howarth, K More by this author
Mallappa, S More by this author
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Journal:
Gut
Volume:
62
Issue:
1
Pages:
83-93
Publication date:
2013-01-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:05ef8b01-6bb7-44ab-b678-7859db585006
Source identifiers:
245883
Local pid:
pubs:245883

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