Journal article
A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.
- Abstract:
-
OBJECTIVE: Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an optimal but not excessive level of Wnt activation is considered favourable for tumourigenesis. The authors assessed effects of pan-intestinal Wnt activation on tissue homeostasis, taking into account underlying physiological Wnt activity and stem-cell number in each region of the bowel. DESIGN: The authors generated mice tha...
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- Publication status:
- Published
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- Publisher copy:
- 10.1136/gutjnl-2011-301601
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Authors
Bibliographic Details
- Journal:
- Gut
- Volume:
- 62
- Issue:
- 1
- Pages:
- 83-93
- Publication date:
- 2013-01-05
- DOI:
- EISSN:
-
1468-3288
- ISSN:
-
0017-5749
- URN:
-
uuid:05ef8b01-6bb7-44ab-b678-7859db585006
- Source identifiers:
-
245883
- Local pid:
- pubs:245883
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2013
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