- Abstract:
-
Several studies have attempted to confirm the association between the recently reported polymorphism located at position -491 in the transcriptional regulatory region of the Apolipoprotein E (ApoE) gene and Alzheimer's disease (AD). Results have been inconclusive, possibly due to the use of clinically diagnosed subjects and controls only. In this retrospective case-control study of 149 (96 AD and 53 controls) brain samples we show that homozygosity for the -491A variant is associated with an ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0304-3940(99)00126-3
-
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- Journal:
- Neuroscience letters
- Volume:
- 263
- Issue:
- 2-3
- Pages:
- 217-219
- Publication date:
- 1999-03-05
- DOI:
- EISSN:
-
1872-7972
- ISSN:
-
0304-3940
- URN:
-
uuid:05eb0d3f-0216-4f1a-ba51-6b23cb149ee3
- Source identifiers:
-
31466
- Local pid:
- pubs:31466
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.
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