Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapula bones of rachitic mice with development

Journal article

Metabolic bone disorders such as rickets are associated with altered in vivo muscular force distributions on the skeletal system. During development, these altered forces can potentially affect the spatial and temporal dynamics of mineralised tissue formation, but the exact mechanisms are not known. Here we have used a murine model of hypophosphatemic rickets (Hpr) to study the development of the mineralised nanostructure in the intramembranously ossifying scapulae (shoulder bone). Using posi...

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Authors: Karunaratne, A; Davis, G; Hiller, J; Esapa, C; Terrill, N

• Journal: Bone
• Volume: 51
• Issue: 3
• Pages: 553-562
• Publication date: 2012-09-01
• DOI: 10.1016/j.bone.2012.04.021
• ISSN: 8756-3282
• Language: English
• Keywords: Bone mineral properties; Mineralisation; Scanning synchrotron small angle X-ray scattering; X-linked hypophosphatemic rickets; N-ethyl-n-nitrosourea