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Pretransplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: a potential explanation for the blood-transfusion effect.

Abstract:

BACKGROUND: Preoperative blood transfusion has had a significant historic impact on graft outcome in clinical kidney transplantation, and the effect has been widely replicated in many experimental transplant models. Although the mechanisms underlying the blood-transfusion effect are poorly understood, one possibility is that preexposure to alloantigen results in the induction of regulatory cells with the capacity to control the effector arm of the immune response. METHODS: Recent studies in ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Transplantation More from this journal
Volume:
76
Issue:
3
Pages:
449-455
Publication date:
2003-08-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Language:
English
Keywords:
Pubs id:
pubs:135949
UUID:
uuid:05e77a9a-ec86-40dc-b004-251880b56905
Local pid:
pubs:135949
Source identifiers:
135949
Deposit date:
2012-12-19

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