Journal article
Coupled metabolic cycles allow out-of-equilibrium autopoietic vesicle replication
- Abstract:
- We report chemically fuelled out‐of‐equilibrium self‐replicating vesicles based on surfactant formation. We studied the vesicles’ autocatalytic formation using UPLC to determine monomer concentration and interferometric scattering microscopy at the nanoparticle level. Unlike related reports of chemically fuelled self‐replicating micelles, our vesicular system was too stable to surfactant degradation to be maintained out of equilibrium. The introduction of a catalyst, which introduces a second catalytic cycle into the metabolic network, was used to close the first cycle. This shows how coupled catalytic cycles can create a metabolic network that allows the creation and perseverance of fuel‐driven, out‐of‐equilibrium self‐replicating vesicles.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1002/anie.202007302
Authors
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie International Edition More from this journal
- Volume:
- 59
- Issue:
- 46
- Pages:
- 20361-20366
- Publication date:
- 2020-09-03
- Acceptance date:
- 2020-07-23
- DOI:
- EISSN:
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1521-3773
- ISSN:
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1433-7851
- Language:
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English
- Keywords:
- Pubs id:
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1120893
- Local pid:
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pubs:1120893
- Deposit date:
-
2020-07-23
Terms of use
- Copyright holder:
- Engwerda, AHJ et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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