Offsetting virulence and antibiotic resistance costs by MRSA.

Journal article

The prevalence of diverse MRSA (methicillin-resistant Staphylococcus aureus) types in both hospital and community settings is a major health problem worldwide. Here we compare hospital-acquired MRSAs with large type II SCCmec elements with those prevalent in both hospital and community settings with smaller type IV SCCmec elements. We find that the type II but not the type IV SCCmec element causes the bacteria to reduce their levels of costly toxin expression. We compare the relative growth r...

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Authors: Collins, J; Rudkin, J; Recker, M; Pozzi, C; O'Gara, J

• Publication status: Published
• Journal: ISME journal
• Volume: 4
• Issue: 4
• Pages: 577-584
• Publication date: 2010-04-01
• DOI: 10.1038/ismej.2009.151
• EISSN: 1751-7370
• ISSN: 1751-7362
• Language: English
• Keywords: Virulence Factors; Community-Acquired Infections; Virulence; Methicillin-Resistant Staphylococcus aureus; Humans; DNA, Bacterial; Staphylococcal Infections; Cross Infection; Drug Resistance, Bacterial