Journal article

Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

Abstract:: Mutation or epigenetic silencing of the transcription factor C/EBPα is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBPα whereby its expression is inversely correlated with C/EBPα activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiation. Gene expression profiles of leukemia-initiating cells (LICs) from both Sox4 overexpression and murine C/EBPα mutant AML models clustered together but differed from other types of AML. Our data demonstrate that Sox4 overexpression resulting from C/EBPα inactivation contributes to the development of leukemia with a distinct LIC phenotype. © 2013 Elsevier Inc.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Zhang, H., Alberich-Jorda, M., Amabile, G., Yang, H., Staber, P., DiRuscio, A., Welner, R., Ebralidze, A., Zhang, J., Levantini, E., Lefebvre, V., Valk, P., Delwel, R., Hoogenkamp, M., Nerlov, C., Cammenga, J., Saez, B., Scadden, D., Bonifer, C., … Tenen, D. (2013). Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia. Cancer Cell, 24(5), 575–588.

MLA Style

Zhang, H., et al. “Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia.” Cancer Cell, vol. 24, no. 5, Cell Press, 2013, pp. 575–88.

Chicago Style

Zhang, H, M Alberich-Jorda, G Amabile, H Yang, P Staber, A DiRuscio, R Welner, et al. 2013. “Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia.” Cancer Cell 24 (5): 575–88.
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Files:: Sox4 Is a Key Oncogenic Target in C-EBPalpha Mutant Acute Myel...

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Publisher copy:: 10.1016/j.ccr.2013.09.018

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+ Zhang, H More by this author

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+ Alberich-Jorda, M More by this author

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+ Amabile, G More by this author

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+ Yang, H More by this author

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+ Staber, P More by this author

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Publisher:: Cell Press
Journal:: Cancer Cell More from this journal
Volume:: 24
Issue:: 5
Pages:: 575-588
Publication date:: 2013-01-01
DOI:: 10.1016/j.ccr.2013.09.018
EISSN:: 1878-3686
ISSN:: 1535-6108

UUID:: uuid:05e65212-c680-4e57-b607-86d88fabf815
Local pid:: pubs:440202
Source identifiers:: 440202
Deposit date:: 2013-12-12

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Copyright holder:: Elsevier Inc
Copyright date:: 2013
Notes:: Copyright © 2013 Elsevier Inc. Under an Elsevier user license.

Licence:: Other

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