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Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

Abstract:

Mutation or epigenetic silencing of the transcription factor C/EBPα is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but downstream targets relevant for leukemogenesis are not known. Here, we identify Sox4 as a direct target of C/EBPα whereby its expression is inversely correlated with C/EBPα activity. Downregulation of Sox4 abrogated increased self-renewal of leukemic cells and restored their differentiatio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Cell Press
Journal:
Cancer Cell More from this journal
Volume:
24
Issue:
5
Pages:
575-588
Publication date:
2013-01-01
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
UUID:
uuid:05e65212-c680-4e57-b607-86d88fabf815
Local pid:
pubs:440202
Source identifiers:
440202
Deposit date:
2013-12-12

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